Mcub^{tm1c(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Mcub^{tm1c(KOMP)Mbp}
• Name: mitochondrial calcium uniporter dominant negative beta subunit; targeted mutation 1c, Mouse Biology Program, UC Davis
• MGI ID: MGI:5692665
• Synonyms: Ccdc109b^{tm1c(KOMP)Mbp}, Mcub^fl
• Gene: Mcub Location: Chr3:129708609-129763850 bp, - strand Genetic Position: Chr3, 59.56 cM, cytoband H1
• Alliance: Mcub^{tm1c(KOMP)Mbp} page
• IMPC: Mcub gene page

Mutation origin

• Mutant Cell Line: DEPD00536_2_F05
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated excision of the parental Ccdc109b^{tm1a(KOMP)Mbp} allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mcub Mutation: 34 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)