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Targeted Allele Detail
Symbol: Isl1tm4Sev
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 4, Sylvia M Evans
MGI ID: MGI:5691395
Synonyms: Isl1fl:Neo, Isl1 hypo
Gene: Isl1  Location: Chr13:116434817-116446225 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Germline Transmission:  Earliest citation of germline transmission: J:152175
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsExon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. This allele was used to generate Isl1tm2Sev and Isl1tm2.1Sev. Immunohistochemistry confirmed reduced protein expression in the spinal cord. (J:152175)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  23 strains or lines available
Original:  J:152175 Song MR, et al., Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development. 2009 Sep;136(17):2923-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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