Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Isl1tm2.1Sev
Name:	ISL1 transcription factor, LIM/homeodomain; targeted mutation 2.1, Sylvia M Evans
MGI ID:	MGI:5320481
Gene:	Isl1  Location: Chr13:116434817-116446225 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Alliance:	Isl1tm2.1Sev page

Germline Transmission:	Earliest citation of germline transmission: J:184018
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. Recombinase-mediated recombination of This allele was used to generate Isl1tm4Sev removed the neo cassette and exon 4. (J:141110)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:	33 strains or lines available

Original:	J:184018 Itou J, et al., Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
All:	3 reference(s)