Malt1^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Malt1^m3Btlr
• Name: MALT1 paracaspase; mutation 3, Bruce Beutler
• MGI ID: MGI:5688603
• Synonyms: bryce_canyon
• Gene: Malt1 Location: Chr18:65564010-65611959 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition at base pair 65,462,915 (v38) on chromosome 18, or base pair 31,947 in the NC_000084 GenBank genomic region within the donor splice site of intron 10 (2 base pairs from exon 10). The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 178-base pair exon 10 (out of 16 total exons), resulting in a frame-shift and coding of 13 aberrant amino acids followed by a premature stop codon within exon 11 (after amino acid 418). (J:224672)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:224672 Wang K-W, et al., Mutagenetix entry for bryce_canyon. MGI Direct Data Submission. 2015
• All: 1 reference(s)