Yap1^tm2.1Dupa
Targeted Allele Detail

Summary

• Symbol: Yap1^tm2.1Dupa
• Name: yes-associated protein 1; targeted mutation 2.1, Duojia Pan
• MGI ID: MGI:5660284
• Synonyms: Yap^S112A
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm2.1Dupa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct was designed (by site-directed mutagenesis) to substitute a serine for an alanine at codon 112 in exon 2. A loxP-STOP-loxP (LSL) cassette was inserted between exons 1 and 2. Cre-mediated recombination removed the LSL cassette allowing conditional expression of the S112A mutation. (J:223215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 37 strains or lines available

References

• Original: J:223215 Chen Q, et al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015 Jun 15;29(12):1285-97
• All: 1 reference(s)