Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yap1tm2.1Dupa mutation
(0 available);
any
Yap1 mutation
(37 available)
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homeostasis/metabolism
neoplasm
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• administration of the DNA alkylating agent, diethylnitrosamine (DEN), results in the development of massive hepatocellular carcinoma (HCC); in contrast to wild-type mice which do not develop visible carcinomas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation
(3 available);
any
Nf2 mutation
(65 available)
Yap1tm2.1Dupa mutation
(0 available);
any
Yap1 mutation
(37 available)
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endocrine/exocrine glands
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• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver 2 months after adenovirus expressing Cre recombinase (Ad-Cre) injection (Ad-Cre) injection
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liver/biliary system
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• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver 2 months after adenovirus expressing Cre recombinase (Ad-Cre) injection (Ad-Cre) injection
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• mice exhibit an enlarged liver 2 months after Ad-Cre injection
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• mice develop massive bile duct hamarotomas 2 months after Ad-Cre injection as compared to contro
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neoplasm
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• mice develop massive bile duct hamarotomas 2 months after Ad-Cre injection as compared to controls
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growth/size/body
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• mice exhibit an enlarged liver 2 months after Ad-Cre injection
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