Vegfc^{tm2.1(Vegfc)Ali}
Targeted Allele Detail

Summary

• Symbol: Vegfc^{tm2.1(Vegfc)Ali}
• Name: vascular endothelial growth factor C; targeted mutation 2.1, Kari Alitalo
• MGI ID: MGI:5660238
• Synonyms: Vegfc^flox
• Gene: Vegfc Location: Chr8:54530567-54639489 bp, + strand Genetic Position: Chr8, 29.2 cM, cytoband B3
• Alliance: Vegfc^{tm2.1(Vegfc)Ali} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215790
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Vegfc^{tm2.1(Vegfc)Ali} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vegfc (MGI:109124)

• Mutation details: A cassette containing a floxed mouse Vegfc cDNA, a bovine growth hormone polyA signal and a loxP and FRT flanked pgk-neo was inserted replacing 137 bp of genomic sequence at the beginning of the first intron via homologous recombination. Flp mediated recombination removed the neo cassette. (J:215790)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vegfc Mutation: 26 strains or lines available

References

• Original: J:215790 Aspelund A, et al., The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest. 2014 Sep 2;124(9):3975-86
• All: 5 reference(s)