Gabbr2^tm2.1Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr2^tm2.1Bet
• Name: gamma-aminobutyric acid type B receptor subunit 2; targeted mutation 2.1, Bernhard Bettler
• MGI ID: MGI:5659899
• Synonyms: GB2-S892A
• Gene: Gabbr2 Location: Chr4:46662318-46991714 bp, - strand Genetic Position: Chr4, 25.18 cM
• Alliance: Gabbr2^tm2.1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215382
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted in intron 18 and a gt to ag mutation, resulting in an S892A substitution, was introduced into exon 19 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:215382)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr2 Mutation: 63 strains or lines available

References

• Original: J:215382 Adelfinger L, et al., GABAB receptor phosphorylation regulates KCTD12-induced K(+) current desensitization. Biochem Pharmacol. 2014 Oct 1;91(3):369-79
• All: 1 reference(s)