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Tg(tetO-Kras*G12D)#Rdp
Transgene Detail
Nomenclature
Symbol: Tg(tetO-Kras*G12D)#Rdp
Name: transgene insertion, Ronald DePinho
MGI ID: MGI:5648530
Synonyms: TetO_LKrasG12D, tetO_Lox-Stop-Lox-KrasG12D
Transgene: Tg(tetO-Kras*G12D)#Rdp  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-Kras*G12D)#Rdp expresses 1 gene
 
Mutation detailsThe murine Kras containing the G12D mutation is under the control of the tet-operator with a lox-stop-lox cassette inserted between the promoter and the start codon of the Kras open reading frame. Expression of the mutant Kras is dependent on Cre-mediated deletion of the stop cassette. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:186194)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:186194 Ying H, et al., Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27;149(3):656-70
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory