Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr
Transgene Detail

Summary

• Symbol: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr
• Name: transgene insertion 9, John Strouboulis
• MGI ID: MGI:5648204
• Synonyms: HNRPA2B1-rtTA2S-M2
• Transgene: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr Location: unknown
• Alliance: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The rtTA2S-M2 variant is expressed under the control of the hnRNPA2/B1 promoter. An ~8 kb DNA fragment was used that encompasses the human hnRNPA2/B1-CBX3 gene locus CpG island, which includes two divergently transcribed promoters. Seven transgenic lines were established through transmission of the transgene. Transgenic founder 2 had two integration sites, which separated upon breeding to generate lines 2a and 2b. Line 9 is the highest expressing line in all tissues tested, lines 2a and 2b expressed weakly in some tissues, whereas lines 1, 4, 6 and 7 expressed low but detectable levels. Line 9 was expanded and studied further. (J:128742)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128742 Katsantoni EZ, et al., Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island. BMC Dev Biol. 2007;7:108
• All: 7 reference(s)