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Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr
Transgene Detail
Nomenclature
Symbol: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr
Name: transgene insertion 9, John Strouboulis
MGI ID: MGI:5648204
Synonyms: HNRPA2B1-rtTA2S-M2
Transgene: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThe rtTA2S-M2 variant is expressed under the control of the hnRNPA2/B1 promoter. An ~8 kb DNA fragment was used that encompasses the human hnRNPA2/B1-CBX3 gene locus CpG island, which includes two divergently transcribed promoters. Seven transgenic lines were established through transmission of the transgene. Transgenic founder 2 had two integration sites, which separated upon breeding to generate lines 2a and 2b. Line 9 is the highest expressing line in all tissues tested, lines 2a and 2b expressed weakly in some tissues, whereas lines 1, 4, 6 and 7 expressed low but detectable levels. Line 9 was expanded and studied further. (J:128742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:128742 Katsantoni EZ, et al., Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island. BMC Dev Biol. 2007;7:108
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory