Phenotypes associated with this allele

• Allele Symbol: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr
• Allele Name: transgene insertion 9, John Strouboulis
• Allele ID: MGI:5648204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr/0 Tg(tetO-FMR1*,-EGFP)#Rkhu/0	involves: C57BL/6JRj * FVB/N	MGI:5751863

Genotype
MGI:5751863

cx1

• Allelic Composition: Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr/0; Tg(tetO-FMR1*,-EGFP)#Rkhu/0
• Genetic Background: involves: C57BL/6JRj * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:229379 )

• mice treated with doxycycline (dox) starting at 3 weeks of age begin to lose weight after 2 days of dox treatment

liver/biliary system

abnormal liver morphology ( J:229379 )

• marker analysis indicates mitochondrial dysfunction in the liver of dox treated mice

hepatic steatosis ( J:229379 )

• mice treated with dox exhibit mild liver steatosis

pale liver ( J:229379 )

• livers are pale and pink in mice treated with dox

mortality/aging

premature death ( J:229379 )

• mice treated with dox starting at 3 weeks of age die after 5 days of dox treatment

nervous system

nervous system phenotype ( J:229379 )

N • ubiquitin positive inclusions are not seen in mice treated with dox for 4 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fragile X-associated tremor/ataxia syndrome		DOID:0050879	OMIM:300623	J:229379