Tg(H2K^b-lacZ)1Cba
Transgene Detail

Summary

• Symbol: Tg(H2K^b-lacZ)1Cba
• Name: transgene insertion 1, Charles Babinet
• MGI ID: MGI:5645898
• Synonyms: H-2Z1
• Transgene: Tg(H2K^b-lacZ)1Cba Location: unknown Genetic Position: Chr17, Syntenic
• Alliance: Tg(H2K^b-lacZ)1Cba page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Tg(H2K^b-lacZ)1Cba involves 2 genes/genome features (Tbc1d5, Satb1) View all
• Mutation details: A 2 kb long H-2Kb 5' regulatory sequences, including the promoter was fused to the E. coli lacZ gene. In this line, lacZ expression in the brain cortex is exactly restricted to the somatosensory area. This marker was used in combination with embryonic cortex transplantation experiments to monitor the establishment of neocortex regionalization. Futher studies show that the insertion site on Chromosome 17 causes insertional mutagenesis of Tbc1d5 and Satb1, leading to a strong decrease in their expression. H-2Z1 closely reports most of the body and brain expression sites of the Satb1 chromatin remodeling gene including tooth buds, thymic epithelium, pontine nuclei, fastigial cerebellar nuclei, and cerebral cortex. (J:79264, J:184976)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:79264 Cohen-Tannoudji M, et al., Unexpected position-dependent expression of H-2 and beta 2-microglobulin/lacZ transgenes. Mol Reprod Dev. 1992 Oct;33(2):149-59
• All: 5 reference(s)