About   Help   FAQ
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu
Transgene Detail
Nomenclature
Symbol: Tg(CAG-lacZ,-FUS,-EGFP)629Gyu
Name: transgene insertion 629, Gang Yu
MGI ID: MGI:5644690
Transgene: Tg(CAG-lacZ,-FUS,-EGFP)629Gyu  Location: unknown  
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ mice display hindlimb curl

Show the 5 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu expresses 1 gene
 
Mutation detailsThis transgene consists of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter, a floxed lacZ gene, wild-type human FUS cDNA, IRES, and EGFP coding sequences. Cre-excision of the loxP flanked lacZ DNA sequence allows for translation of FUS and EGFP. Two lines were generated: 629 and 638. Line 629 was chosen as a representative line. (J:216672)
Generation of the Tg(CAG-lacZ,-FUS,-EGFP)629Gyu and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu transgenes
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:216672 Sephton CF, et al., Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory