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Picalmtm1.2Tmae
Targeted Allele Detail
Nomenclature
Symbol: Picalmtm1.2Tmae
Name: phosphatidylinositol binding clathrin assembly protein; targeted mutation 1.2, Takahiro Maeda
MGI ID: MGI:5640747
Gene: Picalm  Location: Chr7:89779418-89858655 bp, + strand  Genetic Position: Chr7, 50.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220728
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector contains an FRT-flanked PGK-neo cassette, in reverse orientation, and a 3' loxP site downstream of exon 2, and another loxP site inserted upstream of exon 2. Cre-mediated recombination removed the floxed exon 2 and neo cassette. No protein is detected by Western blot analysis (J:220728)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Picalm Mutation:  35 strains or lines available
References
Original:  J:220728 Ishikawa Y, et al., Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica. 2015 Apr;100(4):439-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory