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QTL Variant Detail
QTL variant: Adacm1C3H/HeJ
Name: autoimmune dacryoadenitis in MRL mice 1; C3H/HeJ
MGI ID: MGI:5640609
QTL: Adacm1  Location: unknown  Genetic Position: Chr1, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


MRL/Mp-lpr/lpr mice spontaneously develop progressive dacryoadenitis and

Sialadenitis. A difference in severity of in these diseases is evident when comparing MRL/Mp-lpr/lpr with C3H/lpr mice allowing for the mapping of these traits in a genome wide scan. From these strains, 527 (MRL/lpr _ C3H/lpr) F2 (MCF2) mice were employed for QTL linkage analysis. Phenotypic analysis for dacryoadenitis and sialadenitis indexed for lesions showed that MRL parents showed a much higher degree for lesions as did C3H parents. Further dacryoadenitis and sialadenitis are inherited as recessive in mice with a MRL background. The mapping was indicated in Table 1 of the reference. The following QTL were observed, in parenthesis is chr location, LOD score, nearest marker, and suggested cM location: Autoimmune dacryoadenitis in MRL mice ; Adacm1 (Chr.1, LOD 4.0, D1Mit187, 64.1 cM), Adacm2 (Chr.2, LOD 3.7, D2Mit285, 88.4 cM), Adacm3 (Chr.5, LOD 3.1, D5Mit136, 63.9 cM), autoimmune sialadenitis in MRL mice, Asm3 (Chr.1, LOD 16.8, D1Mit286, 16.8, 69 cM), Asm4 (Chr.2, LOD 5.6, D2Mit395, 65.3 cM), Asm5 (Chr.2, LOD 5.4,D2Mit22, 82.1 cM).

Original:  J:153376 Kamao T, et al., Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3257-65
All:  1 reference(s)

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