Prmt5^{tm2b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Prmt5^{tm2b(EUCOMM)Wtsi}
• Name: protein arginine N-methyltransferase 5; targeted mutation 2b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5636983
• Gene: Prmt5 Location: Chr14:54744639-54754927 bp, - strand Genetic Position: Chr14, 27.82 cM, cytoband C1
• Alliance: Prmt5^{tm2b(EUCOMM)Wtsi} page
• IMPC: Prmt5 gene page

Mutation origin

• Mutant Cell Line: EPD0160_2_A08
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Prmt5^{tm2a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 7 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739, J:226257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prmt5 Mutation: 44 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 4 reference(s)