Gcgr^tm1.1Mahn
Targeted Allele Detail

Summary

• Symbol: Gcgr^tm1.1Mahn
• Name: glucagon receptor; targeted mutation 1.1, Mehboob A Hussain
• MGI ID: MGI:5636712
• Synonyms: Gcgr^fl
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^tm1.1Mahn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette and left exons 2 through 10 floxed. (J:213148)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 6 strains or lines available

References

• Original: J:213148 Song WJ, et al., Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81
• All: 1 reference(s)