Hmgb1^tm1.1Rshw
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1.1Rshw
• Name: high mobility group box 1; targeted mutation 1.1, Robert F Schwabe
• MGI ID: MGI:5629589
• Synonyms: Hmgb1^f
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1.1Rshw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210631
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 2 through 4 floxed. (J:210631)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 15 strains or lines available

References

• Original: J:210631 Huebener P, et al., High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab. 2014 Mar 4;19(3):539-47
• All: 7 reference(s)