Ntrk1^tm1.1Jcar
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1.1Jcar
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Juan C Arevalo
• MGI ID: MGI:5620208
• Synonyms: TrkAP782S
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1.1Jcar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219326
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A P782S mutation was introduced in exon 17 and an FRT flanked neo cassette was inserted in intron 17 via homologous recombination. Flp-mediated recombination removed the neo cassette. The expressed protein does not bind NEDD4L and is more active upon NGF binding. (J:219326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:219326 Yu T, et al., Regulation of trafficking of activated TrkA is critical for NGF-mediated functions. Traffic. 2011 Apr;12(4):521-34
• All: 2 reference(s)