Map3k4^tm2Flv
Targeted Allele Detail

Summary

• Symbol: Map3k4^tm2Flv
• Name: mitogen-activated protein kinase kinase kinase 4; targeted mutation 2, Richard A Flavell
• MGI ID: MGI:5619285
• Gene: Map3k4 Location: Chr17:12446508-12537683 bp, - strand Genetic Position: Chr17, 8.42 cM
• Alliance: Map3k4^tm2Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90112
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5' to exon 3 and a floxed neomycin resistance cassette was placed 3' to the exon. (J:90112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k4 Mutation: 79 strains or lines available

Notes

This is the allele from which Map3k4 was derived.

References

• Original: J:90112 Chi H, et al., GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J. 2004 Apr 7;23(7):1576-86
• All: 1 reference(s)