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Irf8tm2.1Hm
Targeted Allele Detail
Nomenclature
Symbol: Irf8tm2.1Hm
Name: interferon regulatory factor 8; targeted mutation 2.1, Herbert Morse III
MGI ID: MGI:5618103
Synonyms: IRF8-EGFP
Gene: Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218664
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to replace the stop codon of the endogenous gene with an enhanced green fluorescent protein (EFGP) sequence and polyadenylation sequence, followed by a loxP-flanked neomycin resistance (neo) cassette. Cre-mediated recombination removed the floxed neo cassette. (J:218664)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  24 strains or lines available
References
Original:  J:218664 Wang H, et al., A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J Immunol. 2014 Aug 15;193(4):1766-77
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory