Tlr4^Lps-3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr4^Lps-3Btlr
• Name: toll-like receptor 4; defective lipopolysaccharide response 3 Bruce Beutler
• MGI ID: MGI:5613596
• Synonyms: Lops
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^Lps-3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 66,833,880 (v38) on chromosome 4, or base pair 6,070 in the GenBank genomic region NC_000070. The mutation lies in the splice acceptor site of intron 1 of the 3 exon gene, and affects a thymine base 14 nucleotides from the next exon. One possibility, shown below, is that aberrant splicing may result in skipping of the 167 bp exon 2, utilization of the acceptor splice site from intron 2, and splicing of exon 1 to exon 3. Deletion of exon 2 would result in a frame-shift and the coding of one aberrant amino acid followed by a premature stop codon (the second abnormal codon after exon 1). (J:217295)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 90 strains or lines available

References

• Original: J:217295 Zhang Z, et al., Mutagenetix entry for Lops. MGI Direct Data Submission. 2015
• All: 2 reference(s)