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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr4Lps-3Btlr
defective lipopolysaccharide response 3 Bruce Beutler
MGI:5613596
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr4Lps-3Btlr/Tlr4Lps-3Btlr C57BL/6J-Tlr4Lps-3Btlr MGI:5613601
ht2
 		Tlr4Lps-3Btlr/Tlr4+ C57BL/6J-Tlr4Lps-3Btlr MGI:5613602


Genotype
MGI:5613601
hm1
Allelic
Composition		 Tlr4Lps-3Btlr/Tlr4Lps-3Btlr
Genetic
Background		 C57BL/6J-Tlr4Lps-3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4Lps-3Btlr mutation (0 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:217295 )
• following exposure to lipopolysaccharide (LPS) and aluminum adjuvants
decreased tumor necrosis factor secretion ( J:217295 )
• following exposure to lipopolysaccharide (LPS)




Genotype
MGI:5613602
ht2
Allelic
Composition		 Tlr4Lps-3Btlr/Tlr4+
Genetic
Background		 C57BL/6J-Tlr4Lps-3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4Lps-3Btlr mutation (0 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:217295 )
• intermediate following exposure to lipopolysaccharide (LPS) and aluminum adjuvants
decreased tumor necrosis factor secretion ( J:217295 )
• intermediate following exposure to lipopolysaccharide (LPS)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory