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Foxp3tm2.1(EGFP/cre)Shori
Targeted Allele Detail
Nomenclature
Symbol: Foxp3tm2.1(EGFP/cre)Shori
Name: forkhead box P3; targeted mutation 2.1, Shohei Hori
MGI ID: MGI:5609975
Synonyms: Foxp3GFPCre
Gene: Foxp3  Location: ChrX:7579676-7595243 bp, + strand  Genetic Position: ChrX, 3.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215863
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES and EGFP/cre fusion followed by an FRT-flanked neomycin resistance cassette were inserted into exon 11. Flp-mediated recombination removed the selection cassette. (J:215863)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxp3     Summary of all recombinase alleles driven by Foxp3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  41 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Autoimmune Pancreatitis J:234397.
References
Original:  J:215863 Miyao T, et al., Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity. 2012 Feb 24;36(2):262-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory