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Allele Symbol Allele Name Allele ID |
Foxp3tm2.1(EGFP/cre)Shori targeted mutation 2.1, Shohei Hori MGI:5609975 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased cellularity of spleen
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• pancreas is atrophic and the exocrine structure is almost completely lost
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• early onset of autoimmune exocrine pancreatitis
• total number of cells and frequencies of CD4+ and CD8+ T cells are higher in pancreas and pancreatic lymph nodes
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• increased cellularity of spleen
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• increase in CD4+CD44+ and CD8+CD44+ effector/memory T cells, especially in the pancreatic lymph nodes
• increase in frequencies of both CD4+ and CD8+ T cells, especially those expressing CD44 in the spleen and lymph nodes, indicating an expansion of effector/memory T-cell populations
• the ratios of CD4+CD44+/Treg cells and CD8+CD44+/Treg cells are higher, indicating unbalanced T-cell expansion with dominance of effector/memory T cells versus Treg cells
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• early onset of autoimmune exocrine pancreatitis
• total number of cells and frequencies of CD4+ and CD8+ T cells are higher in pancreas and pancreatic lymph nodes
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• increased cellularity of spleen
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• increase in CD4+CD44+ and CD8+CD44+ effector/memory T cells, especially in the pancreatic lymph nodes
• increase in frequencies of both CD4+ and CD8+ T cells, especially those expressing CD44 in the spleen and lymph nodes, indicating an expansion of effector/memory T-cell populations
• the ratios of CD4+CD44+/Treg cells and CD8+CD44+/Treg cells are higher, indicating unbalanced T-cell expansion with dominance of effector/memory T cells versus Treg cells
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• increased cellularity of lymph nodes
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• mice die from T-cell-mediated autoimmune destruction, especially autoimmune pancreatitis
• presence of mononuclear infiltrates in multiple organs such as the pancreas, liver, lung or heart
• more than 70% of neonatal mice that receive CD4+CD25+ T cells from wild-type mice survive over 3 months without any signs of disease
• neonatal mice that receive CD4+CD25+ T cells from Pdcd1tm1Hon knock-out mice show no signs of disease
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• all males die within 3 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pancreatitis | DOID:4989 |
OMIM:167800 |
J:234397 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the frequency of CD25+ Treg, but not that of CTLA-4+ Treg, cells is reduced
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• the frequency of CD25+ Treg, but not that of CTLA-4+ Treg, cells is reduced
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/24/2023 MGI 6.22 |
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