Wnt5a^tm1.1Krvl
Targeted Allele Detail

Summary

• Symbol: Wnt5a^tm1.1Krvl
• Name: wingless-type MMTV integration site family, member 5A; targeted mutation 1.1, Rejji Kuruvilla
• MGI ID: MGI:5605689
• Synonyms: Wnt5a^fl
• Gene: Wnt5a Location: Chr14:28226707-28249405 bp, + strand Genetic Position: Chr14, 16.8 cM
• Alliance: Wnt5a^tm1.1Krvl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196291
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2 followed by a second loxP site followed by a frt-flanked neomycin resistance (neo) cassette downstream of exon 2 of the gene. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:196291)

Expression

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt5a Mutation: 40 strains or lines available

References

• Original: J:196291 Ryu YK, et al., An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol. 2013 May 1;377(1):79-89
• All: 24 reference(s)