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Drd1tm2.1Stl
Targeted Allele Detail
Nomenclature
Symbol: Drd1tm2.1Stl
Name: dopamine receptor D1; targeted mutation 2.1, Susumu Tonegawa
MGI ID: MGI:5603761
Synonyms: D1R flx
Gene: Drd1  Location: Chr13:54051183-54055658 bp, - strand  Genetic Position: Chr13, 28.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211355
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was introduced 5' of the targeted gene's single exon and an FRT-loxP-(neo-tk)-FRT-loxP (LFNT) cassette was introduced 3'. Cre-mediated recombination excised the neo cassette, leaving the coding region flanked by loxP sites. (J:101977, J:211355)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd1 Mutation:  27 strains or lines available
References
Original:  J:211355 Sarinana J, et al., Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8245-50
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory