Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm2.1Stl mutation
(1 available);
any
Drd1 mutation
(68 available)
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behavior/neurological
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol
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nervous system
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• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm2.1Stl mutation
(1 available);
any
Drd1 mutation
(68 available)
Tg(Pomc-cre)1Lowl mutation
(1 available)
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behavior/neurological
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit impaired fear memory in 24 hour contextual memory test at multiple time points as compared to control, however, mice exhibit normal cued fear conditioning during tone presentation and have a normal short term memory fear response
• mice exhibit similar fear response between two similar but different contexts, in contrast, controls freeze more in the original (shock) context than in the similar context
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Analysis Tools