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Snhg14tm1Alb
Targeted Allele Detail
Summary
Symbol: Snhg14tm1Alb
Name: small nucleolar RNA host gene 14; targeted mutation 1, Arthur L Beaudet
MGI ID: MGI:5587826
Synonyms: Ube3aATS-stop
Gene: Snhg14  Location: Chr7:58957672-59625507 bp, - strand  Genetic Position: Chr7, 34.04 cM
Alliance: Snhg14tm1Alb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207499
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsA triple polyadenylation sequence and neomycin resistance cassette were inserted into the 3' end upstream of the Ube3a antisense transcript (chr7:66573289 NCBI37/mm9). The selection cassette is in the opposite orientation. qPCR confirmed the absence of transcript beyond the insertion site expression and unsilenced Ube3a transcript expression when the allele is inherited paternally. Maternal transcript expression is not affected. (J:207499)
Generation of the Snhg14tm1Alb allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snhg14 Mutation:  1 strain or line available
References
Original:  J:207499 Meng L, et al., Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model. PLoS Genet. 2013 Dec;9(12):e1004039
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory