Lrrc8atm1.1Geha
Targeted Allele Detail
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Symbol: |
Lrrc8atm1.1Geha |
Name: |
leucine rich repeat containing 8A VRAC subunit A; targeted mutation 1.1, Raif S Geha |
MGI ID: |
MGI:5581436 |
Synonyms: |
Lrrc8a- |
Gene: |
Lrrc8a Location: Chr2:30127781-30153802 bp, + strand Genetic Position: Chr2, 21.41 cM
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Alliance: |
Lrrc8atm1.1Geha page
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Growth retardation, epidermal hyperkeratosis, thin skeletal muscle bundles, vacuolated renal tubular cells, and absence of ovarian corpora lutea in Lrrc8atm1.1Geha/Lrrc8atm1.1Geha mice
Show the 3 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exon 3 and part of the following intron were replaced with a floxed neomycin selection cassette which was subsequently removed by cre excision. Immunoblotting of thymocyte lysates and FACS analysis of splenic T and B cells confirmed the absence of protein expression in homozygous mutant mice.
(J:211308)
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Generation of the Lrrc8atm1.1Geha allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lrrc8a Mutation: |
53 strains or lines available
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Original: |
J:211308 Kumar L, et al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 5;211(5):929-42 |
All: |
2 reference(s) |
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