Prdm6tm1.2Jrld
Targeted Allele Detail
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Symbol: |
Prdm6tm1.2Jrld |
Name: |
PR domain containing 6; targeted mutation 1.2, Jurgen Ruland |
MGI ID: |
MGI:5576800 |
Synonyms: |
Prdm6del |
Gene: |
Prdm6 Location: Chr18:53597027-53708976 bp, + strand Genetic Position: Chr18, 29.04 cM
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Alliance: |
Prdm6tm1.2Jrld page
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Edematous swelling and thin myocardium in Prdm6tm1.2Jrld/Prdm6tm1.2Jrld embryos
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:209773
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Parent Cell Line: |
E14K (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 3. An addtional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombiantion removed exon 3. This deletion downstream of the PR domain results in a frameshift and precludes production of a functional protein.
(J:209773)
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Generation of the Prdm6tm1.1Jrld and Prdm6tm1.2Jrld alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prdm6 Mutation: |
28 strains or lines available
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Original: |
J:209773 Gewies A, et al., Prdm6 is essential for cardiovascular development in vivo. PLoS One. 2013;8(11):e81833 |
All: |
1 reference(s) |
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