Phenotypes associated with this allele

• Allele Symbol: Prdm6^tm1.2Jrld
• Allele Name: targeted mutation 1.2, Jurgen Ruland
• Allele ID: MGI:5576800
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm6^tm1.2Jrld/Prdm6^tm1.2Jrld	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL	MGI:5576878
cn2	Prdm6^tm1.1Jrld/Prdm6^tm1.2Jrld Tg(Tagln-cre)1Her/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5576877

Genotype
MGI:5576878

hm1

• Allelic Composition: Prdm6^tm1.2Jrld/Prdm6^tm1.2Jrld
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Edematous swelling and thin myocardium in Prdm6^tm1.2Jrld/Prdm6^tm1.2Jrld embryos

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:209773 )

• fewer than expected mice are present beyond E10.0 with no viable mice born

prenatal lethality, complete penetrance ( J:209773 )

• fewer than expected mice are present beyond E10.0 with no viable mice born

cardiovascular system

cardiovascular system phenotype ( J:209773 )

N • vascular smooth muscle cells exhibit normal differentiation, recruitment and proliferation

abnormal angiogenesis ( J:209773 )

• impaired angiogenic patterning with reduced avascular spaces and increased mean vessel diameter in the yolk sac vasculature

abnormal vitelline vasculature morphology ( J:209773 )

• after E13.5 with clusters of growing and partially dilated blood microvessels

• however, large vessel vascularization occurs and a small vessel network is present

thin myocardium ( J:209773 )

integument

pallor ( J:209773 )

• at E12.5

homeostasis/metabolism

edema ( J:209773 )

• at E12.5

embryo

abnormal vitelline vasculature morphology ( J:209773 )

• after E13.5 with clusters of growing and partially dilated blood microvessels

• however, large vessel vascularization occurs and a small vessel network is present

muscle

thin myocardium ( J:209773 )

Genotype
MGI:5576877

cn2

• Allelic Composition: Prdm6^tm1.1Jrld/Prdm6^tm1.2Jrld; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Massive hemorrhage in Prdm6^tm1.1Jrld/Prdm6^tm1.2Jrld; Tg(Tagln-cre)1Her lungs

mortality/aging

neonatal lethality, incomplete penetrance ( J:209773 )

• newborn mice die within 2 days after birth

postnatal lethality, complete penetrance ( J:209773 )

• newborn mice die within 2 days after birth

cardiovascular system

lung hemorrhage ( J:209773 )

• massive

respiratory system

lung hemorrhage ( J:209773 )

• massive