Cep19^tm1.1Jmgi
Targeted Allele Detail

Summary

• Symbol: Cep19^tm1.1Jmgi
• Name: centrosomal protein 19; targeted mutation 1.1, John Martignetti
• MGI ID: MGI:5576737
• Gene: Cep19 Location: Chr16:31918618-31926875 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Cep19^tm1.1Jmgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted dowsntream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. (J:206667)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep19 Mutation: 18 strains or lines available

References

• Original: J:206667 Shalata A, et al., Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. Am J Hum Genet. 2013 Dec 5;93(6):1061-71
• All: 1 reference(s)