Lmna^tm10Lgf
Targeted Allele Detail

Summary

• Symbol: Lmna^tm10Lgf
• Name: lamin A; targeted mutation 10, Loren G Fong
• MGI ID: MGI:5571497
• Synonyms: Lmna^PLAO-C, Lmna^plao-utr
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm10Lgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Introns 10 and 11 of Lmna were deleted thereby abolishing production of lamin C and producing only prelamin A. The lamin C 3' UTR replaced the endogenous prelamin A 3' UTR and a floxed neomycin resistance cassette was inserted downstream of the modified 3' UTR. Western blot analysis confirmed the increased expression of lamin A protein in cerebral cortex and the cerebellum. (J:207144)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 82 strains or lines available

References

• Original: J:207144 Jung HJ, et al., New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet. 2014 Mar 15;23(6):1506-15
• All: 2 reference(s)