Pde10a^tm1Smsh
Targeted Allele Detail

Summary

• Symbol: Pde10a^tm1Smsh
• Name: phosphodiesterase 10A; targeted mutation 1, Sean M Smith
• MGI ID: MGI:5568702
• Gene: Pde10a Location: Chr17:8744204-9205480 bp, + strand Genetic Position: Chr17, 4.96 cM
• Alliance: Pde10a^tm1Smsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 2,756 bp between exon 16 and 17. (J:209032)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde10a Mutation: 60 strains or lines available

References

• Original: J:209032 Nawrocki AR, et al., Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance. Diabetes. 2014 Jan;63(1):300-11
• All: 1 reference(s)