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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ursula Zimber-Strobl
MGI ID: MGI:5567929
Synonyms: LMP1/CD40flSTOP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice develop mono- and oligoclonal lymphomas

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:137122
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs expresses 1 gene
Mutation detailsThe targeting construct introduced into the locus a floxed neomycin resistance/stop cassette and a fusion of the EBV B95-8 strain Lmp1 coding sequence encoding amino acids 1-190 and the human cDNA encoding amino acids 223-280. This fusion generates a constitutively active receptor that is only expressed after cre-mediated removal of the stop cassette. (J:137122)
Generation of the Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  510 strains or lines available
Original:  J:137122 Homig-Holzel C, et al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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