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Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ursula Zimber-Strobl
MGI ID: MGI:5567929
Synonyms: LMP1/CD40flSTOP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice develop mono- and oligoclonal lymphomas

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137122
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs expresses 1 gene
 
Mutation detailsThe targeting construct introduced into the locus a floxed neomycin resistance/stop cassette and a fusion of the EBV B95-8 strain Lmp1 coding sequence encoding amino acids 1-190 and the human cDNA encoding amino acids 223-280. This fusion generates a constitutively active receptor that is only expressed after cre-mediated removal of the stop cassette. (J:137122)
Generation of the Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  510 strains or lines available
References
Original:  J:137122 Homig-Holzel C, et al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory