Myh9^tm9.1Rsad
Targeted Allele Detail

Summary

• Symbol: Myh9^tm9.1Rsad
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 9.1, Robert S Adelstein
• MGI ID: MGI:5566899
• Synonyms: Myh9^E1841K
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^tm9.1Rsad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175367
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A G-to-A mutation was introduced into exon 39, changing glutamic acid codon 1841 (GAG) to lysine (AAG) (p.E1841K). A loxP site flanked neomycin selection cassette was inserted into intron 38 but later excised through Cre-mediated recombination. This modification replicates a mutation associated with a human MYH9-related disease (MYH9-RD). (J:175367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 217 strains or lines available

References

• Original: J:175367 Zhang Y, et al., Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119(1):238-5
• All: 4 reference(s)