Mir128-1^tm1.2Ans
Targeted Allele Detail

Summary

• Symbol: Mir128-1^tm1.2Ans
• Name: microRNA 128-1; targeted mutation 1.2, Anne Schaefer
• MGI ID: MGI:5563794
• Synonyms: miR-128-1^-
• Gene: Mir128-1 Location: Chr1:128130098-128130167 bp, + strand Genetic Position: Chr1, 55.8 cM
• Alliance: Mir128-1^tm1.2Ans page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205260
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT flanked neo cassette were inserted upstream of the microRNA region and a loxP site was inserted downstream of the region. Recombinase mediated recombination removed the neo cassette and the microRNA coding region. Expression of Mir128 was reduced by 20% in the brain of homozygous mice. (J:205260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir128-1 Mutation: 1 strain or line available

References

• Original: J:205260 Tan CL, et al., MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 2013 Dec 6;342(6163):1254-8
• All: 2 reference(s)