Tnfsf15^tm1Hluo
Targeted Allele Detail

Summary

• Symbol: Tnfsf15^tm1Hluo
• Name: tumor necrosis factor (ligand) superfamily, member 15; targeted mutation 1, Hongyu Luo
• MGI ID: MGI:5563219
• Gene: Tnfsf15 Location: Chr4:63642837-63663296 bp, - strand Genetic Position: Chr4, 34.06 cM
• Alliance: Tnfsf15^tm1Hluo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207029
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. Flow cytometry confirmed the absence of protein expression on T cells. (J:207029)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf15 Mutation: 19 strains or lines available

References

• Original: J:207029 Wang X, et al., TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol. 2013 Dec 1;191(11):5420-9
• All: 1 reference(s)