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Targeted Allele Detail
Symbol: Sirt3tm1.1Auw
Name: sirtuin 3; targeted mutation 1.1, Johan Auwerx
MGI ID: MGI:5556075
Synonyms: Sirt3L2
Gene: Sirt3  Location: Chr7:140863666-140882309 bp, - strand  Genetic Position: Chr7, 86.07 cM, cytoband F4
Germline Transmission:  Earliest citation of germline transmission: J:207274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting vector is designed to insert loxP sites flanking exons 2-3 of the gene, and a FRT-flanked neomycin selection cassette was inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:207274)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt3 Mutation:  17 strains or lines available
Original:  J:207274 Fernandez-Marcos PJ, et al., Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2012;2:425
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory