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Nle1tm1.1Cota
Targeted Allele Detail
Nomenclature
Symbol: Nle1tm1.1Cota
Name: notchless homolog 1; targeted mutation 1.1, Michel Cohen-Tannoudji
MGI ID: MGI:5553357
Synonyms: Nle1flox
Gene: Nle1  Location: Chr11:82900768-82908411 bp, - strand  Genetic Position: Chr11, 50.3 cM
Severe hypocellularity in Nle1tm1Cba/Nle1tm1.1Cota Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ bone marrow, with capillaries saturated with erythrocytes

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204063
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the resistance cassette and left exons 4 through 9 floxed. (J:204063)
Generation of the Nle1tm1.1Cota and Nle1tm1.2Cota alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nle1 Mutation:  0 strains or lines available
References
Original:  J:204063 Le Bouteiller M, et al., Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med. 2013 Oct 21;210(11):2351-69
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory