Glra2^tm1.2Lngu
Targeted Allele Detail

Summary

• Symbol: Glra2^tm1.2Lngu
• Name: glycine receptor, alpha 2 subunit; targeted mutation 1.2, Laurent Nguyen
• MGI ID: MGI:5550561
• Gene: Glra2 Location: ChrX:163912013-164110389 bp, - strand Genetic Position: ChrX, 76.75 cM
• Alliance: Glra2^tm1.2Lngu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202763
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 7, which contains the membrane spanning domains M1-M3. An additional loxP site was inserted dowsntream of exon 7. Cre-mediated recombination removed the selection cassette and exon 7. (J:202763)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glra2 Mutation: 9 strains or lines available

References

• Original: J:202763 Avila A, et al., Glycine receptor alpha2 subunit activation promotes cortical interneuron migration. Cell Rep. 2013 Aug 29;4(4):738-50
• All: 6 reference(s)