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H2-Ab1tm1Wug
Targeted Allele Detail
Nomenclature
Symbol: H2-Ab1tm1Wug
Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Gregory F Wu
MGI ID: MGI:5543894
Synonyms: IAbetabstopf
Gene: H2-Ab1  Location: Chr17:34263227-34269418 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204951
Parent Cell Line:  LK-1/LK1 (ES Cell)
Strain of Origin:  C57BL/6NHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance/STOP cassette was inserted into intron 1. Flow cytometry confirmed the absence of protein expression in the peripheral blood, spleen and bone marrow. (J:204951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:  48 strains or lines available
References
Original:  J:204951 Archambault AS, et al., Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol. 2013 Jul 15;191(2):545-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory