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Targeted Allele Detail
Symbol: Car7tm1.1Kkai
Name: carbonic anhydrase 7; targeted mutation 1.1, Kai Kaila
MGI ID: MGI:5543604
Gene: Car7  Location: Chr8:105261326-105276979 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:200079
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin resistance cassette inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed the neomycin resistance cassette and exons 5 through 7. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:200079)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Car7 Mutation:  13 strains or lines available
Original:  J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory