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Kidins220tm1.2Fces
Targeted Allele Detail
Nomenclature
Symbol: Kidins220tm1.2Fces
Name: kinase D-interacting substrate 220; targeted mutation 1.2, Fabrizia Cesca
MGI ID: MGI:5527339
Gene: Kidins220  Location: Chr12:24974925-25063152 bp, + strand  Genetic Position: Chr12, 8.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203073
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed corresponding cDNA with a polyadenylation sequence was inserted upstream of exon 16. An IRES, lacZ and polyadenylation sequence followed by an FRT-flanked neomycin resistance cassette replaced exon 17. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the cDNA. Western blot analysis confirmed the absence of protein expression in E18 embryos. (J:203073)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kidins220 Mutation:  1 strain or line available
References
Original:  J:203073 Cesca F, et al., Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012 Feb;19(2):194-208
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory