Tg(Ccl19-cre)489Biat
Transgene Detail

Summary

• Symbol: Tg(Ccl19-cre)489Biat
• Name: transgene insertion 489, Biomodels Austria
• MGI ID: MGI:5526991
• Synonyms: Ccl19-Cre, transgene insertion 489, Thomas Ruelicke
• Transgene: Tg(Ccl19-cre)489Biat Location: unknown
• Alliance: Tg(Ccl19-cre)489Biat page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ccl19-cre)489Biat expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ccl19 (MGI:1346316)

• Mutation details: A truncated human CD4-IRES-cre sequence with a stop codon was inserted into exon 1 of Ccl19 at the ATG translational start codon in a BAC (RP23446D10). Ccl21b, which is located very close to Ccl19 in the BAC, was disrupted by inserting the human CD8 gene into the first exon. Seven founders were generated and screened by crossing to R26-EYFP reporter mice. 2 of 7 lines had identical stromal-cell specific transgene expression, and founder line 1 was used for all subsequent studies. (J:203158)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ccl19 (mouse) Summary of all recombinase alleles driven by Ccl19. Alliance mouse Ccl19 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:203158 Chai Q, et al., Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity. 2013 May 23;38(5):1013-24
• All: 42 reference(s)