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Pde8btm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Pde8btm1Dgen
Name: phosphodiesterase 8B; targeted mutation 1, Deltagen
MGI ID: MGI:5526098
Gene: Pde8b  Location: Chr13:95024454-95250336 bp, - strand  Genetic Position: Chr13, 49.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203335
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 14 and 15, encoding the catalytic domain, were replaced with a lacZ gene with a nuclear localization sequence, a neomycin resistance gene and stop codons. Western blot analysis confirmed the absence of protein expression in the adrenal glands. (J:203335)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde8b Mutation:  37 strains or lines available
References
Original:  J:203335 Tsai LC, et al., The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol. 2011 Apr;79(4):639-48
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory