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Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Charles L Sawyers
MGI ID: MGI:5524275
Synonyms: Rosa26ERG
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200002
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key expresses 2 genes
 
Mutation detailsThe targeting construct introduced into the locus a splice acceptor sequence, floxed neomycin resistance STOP (4x polyadenylation sequence) cassette, fusion of human TMPRSS2 (exon 1) and ERG (exon 4), IRES, nuclear localized EGFP and polyadenylation sequence. (J:200002)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  741 strains or lines available
References
Original:  J:200002 Chen Y, et al., ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013 Aug;19(8):1023-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory