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Fbxw7tm2Iaai
Targeted Allele Detail
Nomenclature
Symbol: Fbxw7tm2Iaai
Name: F-box and WD-40 domain protein 7; targeted mutation 2, Iannis Aifantis
MGI ID: MGI:5524152
Synonyms: Fbxw7R468Neo
Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200006
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 11 was replaced with a floxed neomycin resistance cassette and a modified exon 11 in which nucleotide substitutions (CGG to TGC) result in the amino acid substitution of cysteine for arginine at position 468 (R468C). (J:200006)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  64 strains or lines available
References
Original:  J:200006 King B, et al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory