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Nfat5tm1.1Itl
Targeted Allele Detail
Nomenclature
Symbol: Nfat5tm1.1Itl
Name: nuclear factor of activated T cells 5; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID: MGI:5522568
Synonyms: TonEBPfl
Gene: Nfat5  Location: Chr8:107293470-107379517 bp, + strand  Genetic Position: Chr8, 53.93 cM, cytoband D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201429
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the neomycin resistance cassette and left exon 4 floxed. (J:201429)
Generation of the Nfat5tm1.1Itl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfat5 Mutation:  2 strains or lines available
References
Original:  J:201429 Wiig H, et al., Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest. 2013 Jul 1;123(7):2803-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory